Arsenic Induces Diabetes

Arsenic is a metalloid element, belongs to V group in"Given widespread exposure to inorganic arsenic from
periodic table, found in the natural environment in somedrinking water worldwide, elucidating the contribution of
abundance in the Earth’s crust and in smallarsenic to the diabetes epidemic is a public health
quantities in rock, soil, water and air. About one third ofresearch priority with potential implications for the
the arsenic in the atmosphere comes from naturalprevention and control of diabetes .
sources, such as volcanoes, and the rest comes fromArsenic induced type 2 diabetes depends on
man-made sources. The mineral (inorganic) forms ofconcentration of arsenic, arsenic compound, time of
arsenic (iAs) are generally more toxic than its moreexposure, biological model. Arsenic induced diabetes
complex organic compounds found naturally in plantalso depends on individual susceptibility which includes:
and animal tissues.genetic factors, nutritional status, health status,
Countries where As levels in drinking water have beendetoxification capability, interactions with other trace
found to exceed the World Health Organizationelements, and presence of other risk factors for
Standard of 10 µg/l include Argentina, Australia,diabetes mellitus.
Bangladesh, chile, China, Hungary, India, Mexico, Peru,The pandemic of arsenic poisoning due to
Taiwan, United States of America. The Nationalcontaminated groundwater in West Bengal, India, and
Academy of Sciences estimates that about 75,000 toall of Bangladesh has been thought to be limited to the
100,000 tons of arsenic is produced annually on aGanges Delta (the Lower Ganga Plain), despite early
global scale. About 80% of arsenic compounds aresurvey reports of arsenic contamination in
used to manufacture products with agriculturalgroundwater in the Union Territory of Chandigarh and
applications such as insecticides, herbicides, fungicides,its surroundings in the northwestern Upper Ganga Plain
algaecides, sheep dips, wood preservatives, dyestuffsand recent findings in the Terai area of Nepal.
and for the eradication of tapeworms in sheep andHigh levels of arsenic above the permissible levels of
cattle. In addition, the use of arsenic in microelectronics50 parts per billion (ppb) are found in the alluvial plains
is increasing. Thus, in addition to water contaminationof Ganges covering six districts of West Bengal.
by this metal, anthropogenic activity is alsoPresence of heavy metals in groundwater is found in
important. Arsenic exposure causes diabetes mellitus40 districts from 13 states, viz., Andhra Pradesh,
besides other toxic effects like Cancerous diseasesAssam, Bihar, Haryana, Himachal Pradesh, Karnataka,
such as: Skin cancer, bladder cancer, liver, lung andMadhya Pradesh, Orissa, Punjab, Rajasthan, Tamil
stomach cancer.Nadu, Uttar Pradesh, West Bengal, and five blocks of
Non-cancerous diseases such as: Peripheral vascularDelhi. There is increase in the prevalence of diabetes
disease, cardiovascular and cerbrovascular diseases,mellitus among residents of arseniasis-endemic areas
hypertension, goitre, hepatomegaly, respiratory systemas compared to residents in non-endemic areas. The
dysfunction, nervous system dysfunction and diabetesspread of arsenic contamination in groundwater
mellitus.seems to be assuming gargantuan proportions. What
Arsenic have been recently proposed as additional riskis worse is that inhabitants of the affected areas are
factors for type 2 diabetes. Hydroarsenicism is aunaware and the local authorities totally oblivious to this
major public health problem since millions of peoplegrave problem. It was known that West Bengal (WB)
worldwide are exposed to arsenic by the drinking ofand Bangladesh had high levels of arsenic in the
contaminated water. An increased prevalalence ofgroundwater, but slowly the problem is spreading to
diabetes has been consistently observed amongother states like Uttar Pradesh. This is confirmed by
residents of high arsenic exposure areas, whereasthe reports of All India Institute of Medical Sciences,
inconsistent findings have been reported fromNew Delhi that people living in the Ballia district of UP
occupational and community-based studies in lowalso have high levels of arsenic in their blood, hair, nails,
arsenic exposure areas. Peoples are exposed toetc.
arsenic through many foods containing small amountsPeople should be made aware that their
of arsenic and water, eating or breathing soil or dustarsenic-related diseases are due to the
particles contaminated with arsenic, drinkingarsenic-contaminated groundwater they are using for
groundwater from natural deposits containing arsenic,drinking and cooking. Lowering of the ingested inorganic
breathing sawdust or burning smoke from woodarsenic level    and introduction    of
treated with arsenic, working in a job that involvesnewer        treatment options (implementation
arsenic production or use, such as copper or leadof laterite, the natural material) to ensure safe water
smelting, wood treating, or pesticide application, touchingsupply (arsenic free and/or low arsenic within
arsenic-containing materialspermissible limit) are the urgent needs to safeguard
Chronic exposure to inorganic arsenic represents a riskagainst mass arsenic poisoning and internal
factor for diabetes mellitus in both environmental andarsenic-related health problems.
occupational. The researchers reportedly concluded: